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Total Ankle Replacement Market – Global Industry Analysis, Trends and Forecast, 2013 – 2019

Total ankle replacement is a surgical process for replacing damaged bones in the ankle joint. Total ankle replacement is performed by placing a plastic or metal implant on top of the ankle bone (talus) and at the end of the shin bone (tibia). Loss of movement and pain in the ankle are the common symptoms. Bone fracture, arthritis, osteoarthritis, and rheumatoid arthritis are some of the primary reasons for total ankle replacement. Arthrodesis and total ankle replacement are the two common types of total ankle replacement surgeries. Recovery period for the total ankle replacement surgery is up to three months after the surgery. Some of the risks associated with ankle replacement are ankle weakness, bone damage during surgery, stiffness, nerve damage, allergic reactions to the artificial joint, and blood vessel damage. Growing awareness about these risks associated with the total ankle replacement surgeries are expected to hamper the growth of the global total ankle replacement market.

The global total ankle replacement market is segmented on the basis of design and geography. By geography, the global total ankle replacement market was dominated by North America in 2013 in terms of revenue and the region is expected to maintain its dominant position throughout the forecast period.

The overview section of the report provides comprehensive data on market drivers, factors limiting the growth of the market, current market trends, market structure, and predictions for the years to come. The report on the global total ankle replacement market is a complete study of changing trends, restraints, and industry growth drivers. The report presents a blueprint that highlights analysis of technology developments. A detailed review of macro and micro factors that are affecting the growth of the market are highlighted in the report. The Porter’s five forces model is used to measure the feasibility of new projects and competitive analysis.

Overview of the Total Ankle Replacement Market

By design, the global total ankle replacement market is classified into agility ankle prosthesis, Buechel-Pappas ankle prosthesis, Scandinavian total ankle replacement (STAR), Salto total ankle replacement, HINTEGRA total ankle replacement, mobility ankle system, TNK total ankle replacement, Ramses total ankle replacement, AES total ankle replacement, BOX total ankle replacement, ESKA ankle prosthesis, German ankle system, alphanorm total ankle replacement, TARIC total ankle replacement, and INBONE total ankle replacement. Based on geography, the global total ankle replacement market is divided into North America, Europe, Asia Pacific, and Rest of the World. The Europe total ankle replacement market is expected to rise due to rising awareness amongst people and the increasing obese population. Asia Pacific is predicted to be the emerging region in the global total ankle replacement market during the forecast period due to increasing awareness about advanced medical technology.

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Risks such as continued pain, mal-alignment, and arthritis development in the adjacent joints are expected to restrict the growth of the global total ankle replacement market in the years to come. However, the growing aging population is a key factor expected to drive the global total ankle replacement market during the period from 2013 to 2019.

Companies mentioned in the research report

Integra Life Sciences, Implants International, Small Bone Innovation, Inc., DePuy Synthes, Zimmer Holdings, Inc., and KYOCERA Medical Corporation are some of the leading companies operating in the global total ankle replacement market. The leading companies are expected to face competition from the emerging companies in the years to come.

Intravascular Ultrasound Devices Market – Latest Innovations, Drivers, Restraints, Challenges and Forecast 2013 – 2019

Intravascular ultrasound (IVUS) is a medical imaging methodology using a specially designed catheter with miniaturized ultrasound probe attached to the distal end. The proximal end of the catheter is attached to computerized ultrasound equipment. It allows application of ultrasonic technology to visualize the blood vessels internally through surrounding blood column. The arteries of the heart (the coronary arteries) are the most frequent imaging target for IVUS. The application of IVUS in coronary arteries is to determine the amount of atheromatous plaque built up at any particular point in epicardial coronary artery. Built up plaque obstructs the blood flow, disturbs the normal blood pressure in body and raises coronary heart complications (e.g. Stenosis). IVUS is a valuable adjunct to angiography, providing new insights in the diagnosis and therapy for coronary diseases. An angiography depicts only 2D silhouette of the lumen, whereas IVUS allows tomographic assessment of lumen area, plaque size, distribution, and composition. According to experts the range of lumen stenosis locations at which myocardial infarctions occur range from areas of acute dilatation all the way to areas of greater than 95% stenosis. However, the average or typical stenoses at which myocardial infarctions occur were found to be less than 50%. Only 14% of the heart attacks occurred at locations with 75% or more due to stenosis. Overall this research has changed the primary focus of heart attack from severe narrowing to vulnerable plaque. According to WHO, it has been estimated that around 17.3 million people died from CVDs in 2008, representing 30% of all the global deaths. Of these deaths, an estimated 7.3 million were due to coronary heart disease and 6.2 million were due to stroke.

The IVUS market can be segmented on the basis of products and applications:


  • IVUS Consoles
  • IVUS Catheters

IVUS Accessories market ( pullback devices, guidewires, others)


  • IVUS coronary diagnostic market
  • IVUS coronary intervention market
  • IVUS coronary research market
  • IVUS non-coronary /peripheral applications market

Some of the major market drivers of Intravascular Ultrasound Devices market are sedentary lifestyle, increasing incidence and prevalence of cardiovascular diseases rising obese population and aging population. Some of the major restraining factors of this market are high cost of diagnostic devices and lack of uniform reimbursement policies. Most of the market experts expect that future research and developments activities in the field will enhance the application range and efficiency of IVUS as it’s currently at initial stage.

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Asia-Pacific market was observed to be the leading IVUS market as Japan represents the largest regional market for intravascular ultrasound worldwide. This was observed due to efficient reimbursement rate and practice pattern in this country. Asia-Pacific was also observed to be the most growing market. North America was observed to be the second largest IVUS market globally as according to Centre for Disease Control and Prevention (CDC), about 5.1 million people in the United States have heart failure and it costs the nation an estimated USD 32 billion each year. High intake of fats through food and lack of physical activities has increased the obese population in North America. Comparatively, reimbursements offered for IVUS in the U.S. are lower and vary significantly among regions of the country. IVUS usage in Europe is also struggling due to the lack of reimbursements in many countries across the region. Rest of the World (RoW) was also observed to be the growing geographic region after Asia-Pacific, especially Latin America and gulf countries were observed to be the major markets for IVUS.

Some of the major key players of the market are Volcano Corporation, Boston Scientific Corporation, Terumo Corporation, Siemens Healthcare, Silicon Valley Medical Instruments Inc., Avinger Inc., InfraReDx Inc., eV3 Endovascular, Inc. (Covedien), among others.

Continuous Glucose Monitoring Market: Business Challenges, Emerging Technologies & Competitive Landscape

Continuous glucose monitoring systems (CGMS) are portable and real-time glucose monitoring systems employed for glucose level measurement from time to time from the body of a patient. These systems make use of a wireless technology for the transmission of glucose readings which are taken from the interstitial fluid of the skin cells of the patient, unlike the measurement of glucose levels present in the blood which happens in case of blood glucose meters. The swiftly increasing diabetic population globally has substantially raised the preference for effectual diabetes management systems.

Transparency Market Research (TMR), a market intelligence company, studies the continuous glucose monitoring market in detail. It provides the reasons behind their increased demand and the type of devices leading the market.

Research Report:


Q. Why are CGMS gaining popularity over the conventionally utilized glucose monitoring systems?

The utilization of CGMS is immensely rising and they are overtaking the conventionally utilized glucose monitoring systems owing to them being user friendly, more accurate, and their provision of presenting access to real-time trends and values. In addition, continuous glucose monitoring systems aid in the management of diabetes, particularly in patients having diabetes I and also aid in lowering long-terms complexities related to diabetes. Furthermore, the increasing technological innovations are also amongst the prime factors behind the increasing employment of these systems, making the control and management of diabetes mellitus relatively simpler. The early identification of hypoglycemic and hyperglycemic levels by the utilization of CGMS devices will also fuel their demand over other types of blood glucose monitoring systems.

Q What are the key opportunities and which factors may negatively impact the growth of the market?

There are numerous growth opportunities in the market as a number of companies have made investments in the research and development of CGMS, thus making the management and control of diabetes easier. For instance, Dexcom, Inc. has developed the next generation disposable continuous glucose monitoring device and it will be introduced in the market by 2021. This launch will positively impact the growth of the market. In addition, the artificial pancreas’ approval, which makes the utilization of CGMS mandatory has also emerged as a key opportunity in the global continuous glucose monitoring devices market. However, the dearth in the reimbursement options and the strict regulatory norms in some nations are amongst the crucial factors impeding the growth of the continuous glucose monitoring market.

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Q. Which device/brand and region have dominated the market?

The segment of Guardian Real Time CGM System led the market in 2012 and was trailed by Dexcom Seven Plus CGM system. On the other hand, in the forecast horizon between 2013 and 2019, the development of the segment of FreeStyle Navigator will witness immense growth.

Geographically, North America held a dominant share in the market for CGMS on the basis of revenue in 2012. This is due to the increasing geriatric population, the increasing obesity, and the growing acceptance of cutting-edge devices in this region. North America was trailed by Europe, which was further followed by Asia Pacific, constituting the third position in the market. In addition, Asia Pacific is predicted to hold the most lucrative opportunities in the growth of the market in forthcoming years.

Increasing Prevalence of Diseases Results in Growth of Global Infusion Pumps Market

Currently, the global infusion pumps market is crowded with many active players introducing a wide variety of specialties across the globe. Key players operating in the global infusion pumps market are focusing on introducing new varieties of insulin pumps, ambulatory pumps, large volume pumps, implantable infusion pumps, disposable pumps, and enteral feeding pumps. Technology advancements have helped companies to focus more on manufacturing disposable infusion pumps, which are in demand among hospitals, clinics, and healthcare centers in many areas.

Top companies including CareFusion Corporation, Baxter International, Inc., B. Braun Melsungen AG, and Hospira, Inc. are taking efforts to enhance their already existing infusion pumps. Transparency Market Research (TMR), in its new report, states that the global market for infusion pumps is expected to witness significant growth owing to the rising aging population. As per the report, the global market recorded US$5.4 bn in 2012 and is predicted to reach US$7.7 bn by 2019, progressing at a 5.30% CAGR.

Research Report:


TMR experts answer the following questions related to the global infusion pumps market, that the companies operating in this market might want to ask:

Q. Will increasing patient base benefit the global market for infusion pumps?

Yes, the increasing patient base is one of the primary factors expected to drive the global market for infusion pumps. Among all health problems, the number of people diagnosed with diabetes is increasing considerably. An uptick in diabetic people is expected to be responsible for the steady expansion of the global infusion pumps market. Apart from this, the market is also expected to be benefited from rising aging population. Technological advancements in the medical devices are predicted to further contribute towards the growth of the global market.

Q. What are the factors expected to restrict the growth of the global infusion pumps market?

Many healthcare clinics and hospitals in various locations reported problems in infusion pumps, leading to product recalls. The patient protection and affordable care act also impose many restrictions on the use of medical devices considering the device problems. Stringent government rules and regulations restrict the entry of new companies in the global infusion pumps market. All these factors are expected to restrict the growth of the global market for infusion pumps in the near future.

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Q. Will new product launches and awareness programs benefit the global demand for new infusion pumps?

Yes, emerging nations are offering many opportunities to manufacturers to introduce their new products in the global market. The availability of enough medical infrastructure is also predicted to benefit manufacturers to launch new products. Many companies are involved in infusion pumps analysis services to reveal key practices that contribute to the smart pump workarounds.

For instance, B. Braun, a leading company was recently in the news for launching its infusion safety analysis service that was designed to assure meaningful use of infusion pumps. The infusion pumps safety analysis service helped reveal top infusions pumps.

The global market for infusion pumps is moving towards smart technology. Key companies are engaged in manufacturing smart infusion pumps with high capacity to avoid errors related to dosing.

Global Apheresis Equipment Market to Reach US$2.3 bn by 2018

The global apheresis equipment market is led by companies such as Asahi Kasei Kuraray Medical Co., Ltd., B. Braun Melsungen AG, Hemacare Corporation, Haemonetics Corp., and Fenwal, Inc. The moderately consolidated global apheresis equipment market is likely to witness further consolidation in the coming years as key players aim to expand their geographical reach and product catalog. Collaborative research efforts and joint development of new product lines is another popular stratagem employed by many key players in the apheresis equipment market.

According to Transparency Market Research, the global apheresis equipment market is set to garner annual revenue of US$1.8 bn by the end of 2016. The annual revenue figure is further expected to rise to US$2.3 bn by the end of 2018.

Asia Pacific Set to Challenge North America’s Dominance

Geographically, North America is the leading contributor to the global market for apheresis equipment. The availability of advanced medical technology and the widespread awareness about the benefit of apheresis in North America are crucial to ensuring sustained growth of the region’s apheresis equipment market. North America held a share of more than 50% in the global apheresis equipment market in 2011, but its share is likely to drop to 44.4% by 2018.

The Asia Pacific market for apheresis equipment is expected to exhibit robust growth over the same period, with a CAGR of 13.49% expected from 2012 to 2018. Though the North America market for apheresis equipment will remain the leading contributor till the end of the forecast period, the investment potential of Asia Pacific is likely to be exploited by key players in the global market, facilitating its rise as a lucrative investment destination for the apheresis equipment industry.

By procedure, plasmapheresis comprises the leading segment of the global apheresis equipment market, holding a majority share of 59.22% in 2011. Despite an expected decline in its market share over the forecast period, plasmapheresis is expected to retain its majority share in the global apheresis equipment market. Photopheresis is another leading segment of the apheresis equipment market and is expected to hold a share of 24.4% in the global market by the end of 2018.

Improving Healthcare Infrastructure in Emerging Countries Drives Demand for Apheresis Equipment

One of the key drivers for the global apheresis equipment market is the steady progress exhibited by the healthcare sector in dynamic emerging economies. The growing awareness about blood donation in urban areas in the developing world has been crucial for the apheresis equipment market, as it has led to the establishment of flourishing blood bank networks and has thus helped provide the infrastructure needed for apheresis.

The increasing therapeutic use of plasma and platelets, which are used in the treatment or management of several diseases, is a crucial driver for the global apheresis equipment market. Plasmapheresis is commonly used in the treatment of several autoimmune diseases, while platelets are vital in managing diseases such as leukemia, the treatment for which damages the patient’s bone marrow. The rising prevalence of such conditions is likely to remain a key driver for the global apheresis equipment market in the coming years.

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High Costs, Risk of Complications Restrict Demand for Apheresis Procedures

One of the key restraints on the global apheresis equipment is the high cost of apheresis procedures. This factor is particularly influential in developing countries, where the absence of adequate reimbursement schemes has left the average consumer at a disadvantage. There is also a lack of trained personnel to operate apheresis equipment in emerging countries, which has emerged as a significant constraining factor.

The risk of contracting diseases through apheresis is one that can’t be denied. This, in addition to the risk of blood pressure complications due to fluctuations in the rate of fluid transfer, has been instrumental in restricting the demand for apheresis. Even though such complications are extremely rare in sophisticated facilities and treatable, they have had a significant negative impact on patient confidence.

The information in this preview comes from a Transparency Market Research report titled ‘Apheresis Equipment Market – Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2012 – 2018.’