Category Archives: Biotechnology

Transformative Effect of Regenerative Medicine on Human Health Benefits Global Market

Global Regenerative Medicine Market: Snapshot

Increasing application areas such as neurology, cardiovascular, musculoskeletal and orthopedic diseases will build up greater opportunities, states TMR. The market for regenerative medicine market appears to be fragmented in terms of competition. The Asia Pacific region will present large opportunities, displaying a promising CAGR between 2013 and 2019. The Asian countries such as South Korea, China, and Japan hold considerable prospects for augmentation of global regenerative medicine market. Smith & Nephew, a British medical equipment manufacturing company acquired Sushrut Surgical Pvt. Ltd., an India-based medical technology firm, enhancing access to the consumer pool in Asian countries in order to secure larger profits.

The global regenerative medicine market was pegged at US$2.5 mn in 2012. It is projected to achieve US$6.4 mn by the end of 2019, expanding at a progressive CAGR of 12.8% during the forecast period.

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North America Leads Due to Increasing Bone and Joint Reconstructive Surgeries

North America, owing to a large number of leading companies operating in regenerative medicine, dominates the global regenerative medicine market. The ongoing expansive research and development activities in the U.S. will also drive the North America segment. The bone and joint regenerative medicine market is the leading application segment in this region, as a high demand for regenerative medicine is exhibited.

The region of Asia Pacific will witness monumental growth because of its massive consumer pool, rising disposable incomes of people, and growing healthcare expenditure. Over the coming years, the regenerative medicine market in Asia Pacific will benefit from the growing demand for orthopedic surgeries, technological innovations, high incidence of joint and bone diseases, and increasing awareness about regenerative medicine. However, the market might face challenges such as high costs and regulatory policies.

Japan displays great potential on account several favorable factors. Fewer regulatory restraints, coupled with technological advancements in the area of regenerative medicine will ensure market expansion in the country. One key technological development is the emergence of 3D tissue bioprinters that enable the creation of blood vessels, cartilage, skin and other tissues.

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Extensive Research in Stem Cell Therapy to Promote Growth

Bio-based alternatives such as stem cell therapy and tissue engineering have gained prominence despite the rapid development of synthetic options. The high generative power of stem cells enables the production of other cells in the body. This feature of stem cells has raised demand for stem cell therapies. Additionally, stem cell therapy is used in the treatment of diseases such as cancer, retinal diseases, Alzheimer’s, diabetes, heart failure treatment, rheumatoid arthritis, autism spectrum, multiple sclerosis, cerebral palsy, and osteoarthritis, among others. It is projected that stem cells will occupy an important portion of regenerative medicine market over the coming period. Therefore, large-scale research activities have been undertaken in order to tap their full potential. However, factors such as ethical issues related to the use of embryonic stem cells might pose a threat to further expansion.

Notwithstanding the advancement of the stem cell therapy segment, the biomaterials segment is expected to retain its foremost position in the global regenerative medicine market. The largest amount of shares were held by this segment in 2012 on account of great demand for biomaterials and supportive reimbursement policies.

The key players operating in the global regenerative medicine market are Stryker Corporation (Vitoss Bone Graft Substitute), DePuy Synthes, Inc. (Healos Bone Graft), CONMED Corporation, Arthrex, Inc., Zimmer Holdings, Inc. (CopiOs Bone Void Filler), and Medtronic, Inc.(INFUSE Bone Graft).


Global Life Science Reagents Industry: PCR Reagent Kits Market to Cannibalize Share of Other Product Markets

Life science refers to the scientific study of biology of living organisms such as human beings, microorganisms, animals and plants. Life science reagents support various life science techniques such as chromatography, flow cytometry and polymerase chain reaction (PCR) to speed up procedures, maintain the pH level of solutions or provide necessary chemical medium. Transparency Market Research (, a leading U.S.-based market research firm, analyzes the global market for life science reagents and predicts a compounded annual growth rate of 10.8% for the period 2013 to 2019.

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The global life science reagents market has experienced tremendous growth in the last few decades. Life science reagents have been in use since 1940’s when cell culture and chromatography techniques were in developmental stage. Completion of human genome project fueled the use life science reagents in the healthcare industry especially in diagnosis and forensic applications. Furthermore, advancement in the field of chromatography, electrophoresis, flow cytometry and in-vitro diagnosis has led to expansion of the application area of these technologies in the healthcare and pharmaceutical industry. Opening out of application areas of biotechnology in pharmaceuticals and healthcare resulted in rapid growth of the life science reagents market.

With expansion in the number of global geriatric population, prevalence of diseases gradually increasing and thus has led to growth in demand for effective and accurate diagnostic tools. Growing in the demand for in-vitro diagnostic solutions is driving the life science reagents market towards growth.

The demand for advanced and improved diagnostic tools is also high in the area of drug research and development. In order to expand their market share in the life science industry, market players are investing heavily on biotechnology and drug research activities in order to introduce novel products in the market. Governments in emerging countries are offering partnerships and encouraging establishment of business clusters to set up biotechnology research facilities. In addition to partnerships, governments are also offering funding and tax benefits to boost the biotechnology industry in their countries. Growth in research activity in the field of biotechnology and drug development is stimulating the growth of life science reagents market.

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Major players in the life science reagents market are increasingly entering the emerging markets of India, Brazil and China due to availability of qualified manpower, currency difference benefits and cheap labor. Furthermore, rapidly growing medical tourism industry in the Asia-Pacific regions will attract international patients, which will ultimately lead to growth in demand for advanced diagnostic tools and medical services. This market is characterized by the presence of several big and small-scale suppliers and thus has rendered it to be fragmented in nature. Some of the major companies contributing to the global life science reagents market are Abbott Laboratories, Agilent Technologies, Sigma Aldrich Corporation, Siemens Healthcare, Merck Millipore and Bio-Rad Laboratories, Inc.

Global Aptamer Market: Advancements in Aptamer Technology to Expand Market at 73.1% CAGR

Aptamers are chemically synthesized single stranded oligonucleotides that are used to inhibit variety of target proteins and antigens. Aptamers specifically bind to a range of micromolar to macromolar molecular targets. They are basically of two types namely nucleic acid aptamers and peptide aptamers. Nucleic acid aptamers have the strand of oligonucleotides while peptide aptamers contain short peptide domain in its structure. Normally aptamers can be generated by the aptamer selection process known as SELEX process. Aptamer technology applies in number of areas such as diagnostics, food safety, research applications and therapeutics in number of industrial sectors like pharmaceutical, research laboratories and biotechnology.

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Transparency Market Research, a leading U.S based market research firm analyses the global market for aptamers and estimates the CAGR of 73.1% for the period 2013 – 2019. This is majorly due to increasing research and development activities by scientists coupled with increasing participation of government and private organizations in the U.S. and U.K. towards the development of this field. For example, in June 2014, Somalogic, Inc. received funding from Bill and Melinda Gates Foundation to develop SOMAmer based tuberculosis biomarker assay for the identification of patient’s tuberculosis.

The other factors such as advancement in aptamer selection technologies coupled with various advantages of aptamers over monoclonal antibodies will further drive the market growth. Several modifications of the SELEX procedure have been introduced to improve aptamer selectivity or to reduce selection time. Subtractive SELEX, automated SELEX and atomic force microscopy-SELEX are some of the modified SELEX processes available for aptamer selection with desired features. Companies like Archemix, Somalogic, Inc. and Aptamer Sciences, Inc. are constantly involved in collaboration strategy with number of biotechnology companies to develop their aptamer business. For example, Archemix collaborated with Elan to discover aptamers for treatment of autoimmune diseases. Thus, these types of collaboration will help companies to develop new aptamers hence drives the market growth. Moreover, large number companies have increased their research expenses on aptamers after first aptamer- Macugen approved by USFDA in 2004. For example, Germany-based NOXXAN Pharma AG has three aptamers namely NOX-E63, NOX A-12 and NOX-H94 under clinical pipeline. NOX-E63 and NOX A-12 are under phase II clinical studies. The approval of these aptamers in future would definitely boost the market growth of aptamers. Other features of aptamers like favorable toxicological property, high stability, ease of synthesis and rapid tissue penetration would significantly contribute to the growth of the market.

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The factors mentioned above are driving the development and commercialization of aptamers worldwide. However, unfavorable regulatory environment, lack of universal rule coupled with lack of knowledge of aptamers among research scientists will restrain the market growth. For example, there is no formal regulatory guideline that can satisfactorily address the quality and safety of aptamer molecule. Additionally, countries like Europe demands tedious documentation to start clinical trials on aptamers which will further restrain the market growth of aptamers.

New Trends of Aptamers Market with Worldwide Industry Analysis to 2019

The growing use of aptamers in drug discovery, pharmaceutical studies, as well as disease treatment will help drive the global aptamers market through the current decade, says Transparency Market Research in a recent study. The report is titled ‘Aptamers Market – Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 – 2019.’ According to the report, the global aptamers market was valued at US$93.0 million in 2012, and it is expected that the market will reach a valuation of US$4,333.0 million by 2019. This translates to a remarkable CAGR of 73.1% between 2013 and 2019.

However, the report also warns that the growth in the global aptamers market will be restrained to some extent ethical issues associated with aptamers derived from animals. This drawback will be further compounded by strict regulatory mandates designed around aptamers. However, these drawbacks can be overcome by companies in the global aptamers market by modifying aptamers chemistry. For instance, animal-derived aptamers can be replaced by aptamers obtained via the in-vitro process.

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For the purpose of this study, the global aptamers market is segmented on the basis of types, applications, and geography. The types of aptamers studied in the report include peptide and nucleic acid aptamers. The segment of nucleic acid aptamers was not only the largest as of 2012, but is also expected to be the fastest growing over the report’s forecast period. This is chiefly owing to the widespread use of nucleic acid aptamers in the R&D sector.

Likewise, the applications analyzed in the report are: Diagnostics, therapeutics development, research and development, and others. Of these, the diagnostics segment will report consistent growth over the next four years as the demand for aptamers for biomedical diagnostics, biomarker development, and molecular imaging remains steady. However, in terms of pace of growth, therapeutics development applications will outpace all other application segments over the report’s forecast period.

From the geographical standpoint, the aptamers market for the following regions is studied: North America, Asia Pacific, Europe, and Rest of the World. Thanks to several key players in the aptamers market being based in the United States, the North America region was identified as the largest market for aptamers in 2012. This factor also creates an environment that fosters R&D related to aptamers.

The Europe aptamers market was the second largest from the global standpoint. According to the findings of the report, Europe constituted about 35% of the global aptamers market in 2012. Small scale industries play a key role in keeping the Europe aptamers market firmly on the growth track. The Asia Pacific market is currently brimming with opportunities in diagnostics and pharmaceuticals, enabling the region to post the highest CAGR between 2013 and 2019.

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TMR’s report also conducts a detailed analysis of the competitive scenario in the global aptamers market, which is characterized by intense competition. A high degree of competition has stimulated higher investments the development of novel aptamers. Leading market participants include: Somalogic, Inc., Aptamer Science, Inc. NOXXAN Pharma AG, and Aptagen, Inc.


Transformative Effect of Regenerative Medicine on Human Health Benefits Global Market

Regenerative medicines are an emerging field of medical science aimed at regeneration, repair, or replacement of damaged tissue and organs. As per the U.S. National Institute of Health, regenerative medicine is the procedure of creating functional tissues to repair and/or replace nonfunctional organs or tissues. With regenerative medicines, tissues or organs that have lost their functioning power due to congenital defects, age, and external or internal damage are repaired or replaced. Some of the application areas of regenerative medicines are neurology, cardiovascular, orthopedic, and musculoskeletal disorders.

Factors such as technological advancements in stem cell therapy and tissue engineering are predicted to propel the global regenerative medicine market during the forecast period. However, ethical issues, post-implantation infections and complications, and regulatory constraints are expected to hamper the growth of the global regenerative medicine market in the years to come. Leading players are focusing on capturing the untapped market to increase their share in the global market. The high number of mergers, acquisitions, and partnerships expected to occur in the coming years is predicted to make the global regenerative medicine market highly competitive in the near future.

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The global regenerative medicine market is segmented on the basis of technology, application, and geography. Based on geography, the global regenerative medicine market is divided into Asia Pacific, Europe, North America, and Rest of the World. In 2012, the global regenerative medicine market was dominated by North America due to the rising demand for bone and joint reconstructive surgeries. The region’s increasing aging population is predicted to propel the Europe regenerative medicine market in the next few years. Going forward, Asia Pacific is expected to register considerable growth in the global regenerative medicine market.

Companies such as DePuy Synthes, Inc. (HEALOS Bone Graft), Stryker Corporation (Vitoss Bone Graft Substitute), Zimmer Holdings, Inc. (CopiOs Bone Void Filler), and Medtronic, Inc. (INFUSE Bone Graft) are expected to lead the global regenerative medicine market in the years to come. The entry of new players is predicted to create new growth opportunities in the near future.

By technology, the global regenerative medicine market is classified into stem cell therapy, tissue engineering, and biomaterials. In 2012, the biomaterials segment dominated the global regenerative medicine market due to factors such as favorable reimbursement policies. Moreover, strong demand for biomaterials is predicted to propel the segment in the coming few years.

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