Gene Delivery System Market is Envisaged to Hit US$ 4,281.0 Mn by 2025

 

Transparency Market Research (TMR) has published a new report titled “Gene Delivery System Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2017–2025”. According to the report, the global gene delivery system market was valued at approximately US$ 2,227.8 Mn in 2016 is projected to expand at a CAGR of over 7.8% from 2017 to 2025, The report suggests that increasing in incidence of chronic diseases, rise in technological advancement in administration of drug delivery are projected to boost the market from 2017 to 2025. Key players introduce advanced technologies for drug delivery systems in North America and Europe; therefore, these regions are likely to account for a dominant share of the global gene delivery system market. Changing lifestyle and increase in incidence of chronic diseases in emerging markets such as China and India are likely to boost the market in Asia Pacific. The market in the region is expected to expand at a CAGR of around 8.6% from 2017 to 2025.

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High Cost of Gene Delivery Systems is a Key Inhibitor for the Global Gene Delivery System Market

The cost of gene delivery system is significantly high, hence it is not affordable to all income groups. Additionally, lack of reimbursement in developing and under developed countries is likely to restrain the market. For instance, the cost of Spinraza, marketed by Biogen and used for the treatment of spinal muscular atrophy, is around US$ 750,000 per patient in the first year and US$ 375,000 annually thereafter. The cost of Cinryze, marketed by Viropharma used for the treatment of hereditary angioedema, is more than US$ 417,000 per patient per year. Moreover, rise in incidence of rare diseases increases the demand for treatment options. This, in turn, increases the cost of treatment due to less availability. Gene delivery targets only the affected region. Hence, stringent regulations lead to drug recalls. Therefore, gene delivery drugs are not sold over-the-counter.

Combined Hybrid Delivery System Segment to Lose Market Share

The report offers detailed segmentation of the global gene delivery system market based on delivery system, application, and route of administration. The delivery system is segmented into viral gene delivery system, non-viral gene delivery system, and combined hybrid delivery system. The combined hybrid delivery system segment is expected to lose market share during the forecast period primarily due to increase in demand for viral gene delivery system. Rise in incidence of genetic disorders with a different pattern of inheritance increases demand for gene delivery systems worldwide. Increase in application of viral gene delivery for the treatment of several chronic diseases such as cancer fuels the segment. The non-viral gene delivery system segment is likely to maintain market share during the forecast period. Several advantages of non-viral vectors over viral vectors such as lack of immunogenicity, low toxicity, and potential for tissue specificity drive the segment.

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Urology Segment to Expand at Considerable Pace during the Forecast Period

Based on application, the oncology segment dominates the global gene delivery system. Increase in incidence of cancer worldwide, drives the segment. According to WHO report (2017), around 1 in 6 deaths occurs due to cancer globally. The urology segment accounted for market share of 7.0% in 2016. The segment is a projected to expand at a considerable pace due to increase in number of chronic kidney diseases and rise in incidences of kidney and liver cancer. According to World Kidney Day a global awareness campaign, 8% to 10% of adults have some form of kidney disorder globally.

Inhalation Segment to Lose the Market Share

In terms of route of administration, the injectable segment dominated the market with share of 43.8%. The injectable route of administration is used for rapid drug absorption. Drugs with low oral bioavailability are administered through intramuscular or subcutaneous route. The inhalation accounted for a small share of the market in 2016; however, is expected to lose market share during the forecast period. Drugs used for the treatment of lung diseases such as bronchodilators and steroids are administered through inhalation to achieve rapid action.

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Asia Pacific to Register Exponential Growth due to Increase in Incidence of Diseases

The market in Asia Pacific is expected to expand at a CAGR of 8.6% during the forecast period. Asia Pacific constituted 19.8% share of the market in 2016. Increase in incidence of several acute and chronic diseases in Asia Pacific drives the market in the region. India has high incidence of infectious diseases such as tuberculosis. According to WHO report (2015), India had 2.8 million tuberculosis patients, which was nearly 27.3% of global TB incidence, followed by Indonesia (9.8%), and China (8.8%). North America and Europe account for significant share of the global gene delivery system market due to increase in prevalence of cancer in these regions. According to WHO report 2016, 31% of all deaths were caused by cancer and 2% by diabetes in France.

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Key Players such as Novartis AG, Amgen Inc., Oxford BioMedia plc, and SIBIONO to Lead the Global Gene Delivery System Market

Leading players operating in the global gene delivery system market include Novartis AG, Amgen Inc., Oxford BioMedia plc., SIBIONO, Shanghai Sunway Biotech Co. Ltd., Pfizer Inc., Bayer AG, Johnson & Johnson Services Inc., Human Stem Cells Institute, and Epeius Biotechnologies Corporation. Strong gene delivery system pipeline to drive the global gene delivery system market.

 

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Ophthalmology Surgical Devices Market is Envisaged to Hit US$ 11.0 Bn by 2025

The global ophthalmology surgical devices market was valued at approximately US$ 7,000.0 Mn in 2016 and is projected to register a compounded annual growth rate (CAGR) of over 4.0% from 2017 to 2025, according to a new report published by Transparency Market Research (TMR) titled “Ophthalmology Surgical Devices Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2017–2025”. The report suggests that technological advancements and presence of leading players is projected to augment the demand for ophthalmology surgical devices in the next few years (from 2017 to 2025). North America dominates the global ophthalmology surgical devices market, due to high preference for surgical procedures for eye treatment in the region. Emerging markets such as China, India, Argentina, and Brazil are likely to promote growth of the market in Asia Pacific and Latin America from 2017 to 2025.

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Strategic Collaborations and High Unmet Needs for Refractive Surgeries to drive Global Ophthalmology Surgical Devices Market

Globally, disorders such as cataract, glaucoma, and age-related macular degeneration (AMD) are the leading causes of blindness and visual impairment. The burden of eye diseases across the globe is expected to increase significantly in the next few years. According to a report published by the World Health Organization (WHO) in 2010, cataract was responsible for causing blindness in 20 million people, which represented around 51% of the world blindness. Glaucoma was estimated to cause blindness in 4.5 million people, which was around 12% of the global blindness. The continuing worldwide demographic trend of people developing myopia is expected to augment the demand for refractive surgeries required to treat the disorder in the next few years. The rate of prevalence of myopia is as high as 70% or more in countries in East Asia. Companies in the ophthalmology surgical devices market are increasingly collaborating with one another as well as with research institutes in order to develop new technologies to address the current unmet needs for eye care. In May 2016, Bausch + Lomb and HOYA Surgical Optics entered into an exclusive agreement, which helped the former to market and commercialize the latter’s wide portfolio of injectors and intraocular lenses (IOLs) in the U.S.

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Glaucoma Surgery Devices Segment to expand at a High Rate

The cataract surgery devices segment dominates the global ophthalmology surgical devices market in terms of revenue. Factors such as launch of new and innovative products, large number of patients with cataract, and government initiatives for promotion of cataract surgeries are likely to fuel the segment during the forecast period. The glaucoma surgery devices segment is estimated to expand at a CAGR of more than 4.0% during the forecast period. Factors such as rising adoption of minimally invasive glaucoma surgeries, increasing elderly population, and growing awareness among people are driving the glaucoma surgery devices segment. According to a study published by the American Academy of Ophthalmology, the prevalence of glaucoma in people aged 40–80 years in the U.S. was 64.3 million in 2013 and is set to increase to 76.0 million by 2020 and 111.8 million by 2040.

Hospitals Segment dominates in terms of Market Share

Based on end-user, the market has been classified into hospitals, ambulatory surgical centers, and ophthalmic clinics. The hospitals segment holds a major market share. The segment is estimated to expand at a CAGR of more than 4.0% during the forecast period. High preference for hospitals by patients with cataract and diabetic retinopathy, presence of a large number of hospitals with highly equipped technologies, and favorable health care insurance coverage are key factors driving the hospitals segment. The segment is likely to be followed by the ophthalmic clinics segment in the next few years. Increase in the number of ophthalmologists and independent optometrists is a key fueling factor for the ophthalmic clinics segment.

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Asia Pacific to offer High Incremental Opportunity

In terms of value, North America led the global ophthalmology surgical devices market in 2016. Rapid adoption for newer technologies and large pool of patients with eye diseases are factors responsible for the major share held by North America in the global market. However, various governments in the region are offering funds for R&D, encouraging pioneering research in the field of ophthalmic laser. Europe is the second-largest market for ophthalmology surgical devices. Increasing baby boomer population and rising incidence of eye disorders in the region are likely to propel the Europe ophthalmology surgical devices market during the forecast period. Increased participation of governments in the development of health care infrastructure and increasing disposable income of people in the region fuel the Asia Pacific ophthalmology surgical devices market. The market in Middle East & Africa was valued at approximately US$ 190.0 Mn in 2016 and is likely to expand at a CAGR of more than 3.0% from 2017 to 2025. Latin America and Middle East & Africa are likely to offer immense growth opportunities to the ophthalmology surgical devices market during the forecast period. Large number of cataract surgeries performed in countries such as Argentina and Bolivia, significant improvements, and initiatives by governments in these regions are factors that fuel the ophthalmology surgical devices market in Latin America and Middle East & Africa.

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Key Players such as Alcon, Johnson & Johnson, Vision Care, Inc., and Carl Zeiss Meditec AG to continue to lead Global Ophthalmology Surgical Devices Market

The report also provides profiles of leading players operating in the global ophthalmology surgical devices market such as Alcon, Carl Zeiss Meditec AG, Johnson & Johnson Vision Care, Inc., Bausch & Lomb, Inc., IRIDEX Corporation, Lumenis Ltd., NIDEK CO., LTD., STAAR Surgical Company, HOYA Corporation, and Glaukos Corporation. Launch of new products and strengthening of product distribution channels across different geographies are key strategies adopted by several major players. Carl Zeiss Meditec AG aims to maintain balanced distribution of revenues across individual markets. The company currently generates around 33% of its revenues from the market in EMEA, the Americas, and APAC.

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Circular Dichroism Spectrometers Market is Envisaged to Hit US$ 51.0 Mn by 2025

 

The global circular dichroism (CD) spectrometers market was valued at approximately US$ 28.0 Mn in 2016 and is projected to register a CAGR of more than 6.0% from 2017 to 2025, according to a new report titled, “Circular Dichroism (CD) Spectrometers Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2017–2025” published by Transparency Market Research. The report suggests that technical advancement in CD spectroscopy, in terms of new modality, is expected to expand its applications, thereby boosting the demand for the product during the period, 2017 to 2025. As key players introduce their advanced CD spectrometers and new add-on accessories in the developed markets such a North America and Western Europe, these regions are projected to account for a dominating share of the global CD spectrometers market. Surge in public and private sector funding for R&D programs in the emerging markets such as China and India is projected to boost the growth of the CD spectrometers market in Asia Pacific at a CAGR of around 7.0% from 2017 to 2025.

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Expanding applications of FDCD and Stopped Flow CD in proteomics study to boost CD spectrometer uptake

CD spectrometers are a type of analytical instrument used to study the molecular structure and chiral activity of biomolecules and other organic compounds. CD spectrometers are widely used in the study of proteins, DNA, and their conjugates. Earlier, CD spectrometers had limited applications which had restricted their adoption to academic institutes only. In recent times, key suppliers and researchers in CD spectrometers have developed new modalities of the product, such as fluorescence detected CD, magnetic CD, vibrational CD, circularly polarized luminescence (CPL), and stopped flow CD, which have supported researchers to perform in-depth study of biomolecule’s molecular structure and chiral activity at their ground state, photon excitation state, and also the impact of various factors such as temperature, pH, salinity, etc. on these attributes. As the pharmaceutical industry and researchers are hiking their R&D expenditure on new therapeutic entities such as biological drugs, demand for CD spectrometers is anticipated to surge up. However, CD spectrometer is an expensive capital equipment, which requires specialized infrastructure and skilled workforce. Moreover, use of alternative analytical tools such as Raman spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscope, and X-ray crystallography is anticipated to restrain the uptake of CD spectrometers.

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Multiple Light Source CD Spectrometers to Gain Market Share

The report offers detailed segmentation of the global circular dichroism (CD) spectrometers market based on product and end-user. Among the product types studied, the circularly polarized light sources segment is poised to account for the leading share of the global market during the forecast period from 2017 to 2025. The circularly polarized light sources CD spectrometers segment is expected to get a boost due to high demand for the product in the emerging markets; easy assembly and operation and comparatively low price of these spectrometers are the factors driving their market share. The multiple light sources CD spectrometers segment is anticipated to witness rapid expansion during the forecast period at a CAGR of around 7.0%. These CD spectrometers provide chiral activity’s study of a biomolecule at various wavelengths and in shorter time. The linearly polarized light sources segment is estimated to lose its market share during the forecast period from approximately 16.0% in 2016 to approximately 15.0% by 2025.

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Government and Private Research Organizations in Emerging Markets Poised to be Lucrative End-users

Among end-users, government and private research organizations are the leading contributors to the global CD spectrometers market. The segment is projected to constitute the dominant share of the global CD spectrometers market during the forecast period and is estimated to expand at a CAGR of around 7.0% from 2017 to 2025. Upsurge in funding from the public and private sectors for various research programs in developed markets is anticipated to propel this growth. Rising number of government and private institutes and universities in the emerging markets such as China, India, and Southeast Asia is estimated to fuel the market. Contract research organizations (CRO) is projected to be an emerging end-user segment of CD spectrometers in the emerging markets.

Asia Pacific to Resister Exponential Growth and Offer Huge Incremental Opportunity

In terms of value, North America was the leading contributor to the global circular dichroism (CD) spectrometers market in 2016. High public and private sector funding for research programs in the U.S. is one of the contributing factors toward the major share of the CD spectrometers market in the region. Stringent regulations and policies regarding documentation of the chiral nature of drug entities in the U.S. is leading the pharmaceutical industry and CROs to adopt analytical tools such as CD spectrometers. According to the National Center for Science and Engineering Statistics (NCSES), expenditure on R&D in the U.S. increased at a CAGR of 4% from 2013 to 2015. The trend is estimated to continue in the near future. Increasing cost of R&D processes and stringent rules and regulations for R&D in the developed regions such as the U.S. and Western Europe are compelling pharmaceutical companies to outsource their R&D activities to CROs in Asia Pacific. Moreover, initiatives undertaken by governing bodies in the region to develop higher education infrastructure is expected to fuel the CD spectrometers market in Asia Pacific at a CAGR of around 7.5% from 2017 to 2025.

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Key Players such as AstraZeneca, Bayer AG and Merck & Co., Inc. are Likely to Continue to Lead the Global Cardiovascular Drugs Market

The report also provides profiles of leading players operating in the global circular dichroism (CD) spectrometers market such as Jasco, Applied Photophysics Ltd., Bio-Logic Science Instruments, Inc., Aviv Biomedical, Inc., On-Line Instrument Systems, Inc. (Olis), and Bruker. Most of these key players emphasize on development of new CD modalities such as fluorescence detected CD, stopped flow CD, vibrational CD, etc. These modalities are offered as an add-on accessory or standard feature of CD spectrometer. Expansion of geographic reach through collaborations and distribution agreements is a key strategy adopted by these key players; for example, Hinds Instruments, a manufacturer of photoelastic modulators, has developed microplate CD reader and licensed it to Bio-Logic Science Instruments, Inc. for global distribution.

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Gynecological Devices Market to Become Worth US$22,589.9 mn by 2023

 

The global gynecological devices market is marked by a high degree of fragmentation due to the presence of several large and small manufacturers, reports Transparency Market Research (TMR) in a new business intelligence study. This leaves ample room for market consolidation in the near future. Nevertheless, top companies namely Boston Scientific Corporation, Cooper Surgical, and Olympus Corporation hold prominence on account of their extensive product portfolio and geographical outreach. These companies are vying to introduce non-invasive devices to serve a larger consumer base that will also help expand their geographical outreach. With increasing demand for medical help for women-centric health issues, there lies immense scope of growth for players in the gynecological devices market.

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At present, small as well as regional players hold significant share in the gynecological devices market. However, increasing entry barriers and stringent regulations for product approval are limiting the entry of new companies. Insufficient funding from venture capitalists is also challenging new companies to enter this market.

As per projections of a TMR report, the global gynecological devices market will clock 4.8% CAGR between 2017 and 2023. This will translate opportunities in the market to generate a revenue of US$22,589.9 mn by 2023 from US$17,015.9 mn in 2017. In terms of device type, gynecological surgical devices hold prominence in the market. Rising prevalence of single incision laparoscopic surgeries and advances in conventional endoscopic surgeries account for advances in gynecological surgical instruments. Geography-wise, North America is a lucrative market for gynecological devices due to the early adoption of advanced gynecological devices.

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Efforts of Global Health Organizations for Women Health a Boon for Market

First and foremost, rising incidence of gynecological disorders such as uterine fibroids, cervical cancer, and menorrhagia is driving the gynecological devices market. In developing countries, healthcare infrastructural development and technologically advanced diagnostic services is favoring the gynecological devices market. An increasing awareness among women in these countries regarding therapeutics for gynecological diseases is also stoking demand for gynecological devices. Global health organizations and non-profit organizations conduct periodic health check-ups in developing and underdeveloped countries for women health. This stokes demand for gynecological devices.

In urban areas, modern lifestyle and increasing professional and personal stress are also related to gynecological conditions. This is necessitating routine check-up for women-centric health issues that may require gynecological devices at secondary stage of therapeutics.

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Rising Preference for Minimally Invasive Procedures Stokes Demand

At present, acceptance of minimally invasive procedures generally is on the rise. This is because minimally invasive surgeries involve shorter hospital stay and faster recovery. Minimal scarring and ease of post-surgery care are leading individuals to opt for minimally invasive procedures. Gynecological surgery at one time meant big painful incisions, longer recovery periods, and intense monitoring. Due to this, open exposure surgical hysterectomies is increasingly being replaced with minimally invasive hysterectomies that involve the use of an electric morcellator surgical device.

Increasing public and personal healthcare expenditures and rising awareness of therapeutics for gynecological diseases in developing countries is cementing the growth of this market. Women health in these countries is increasingly being considered important for economic development thus drawing the attention of national governments.

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However, long hauls for product approval and delays for product approval from regulatory authorities is providing headwinds to the growth of gynecological devices market. Stringent documentation and compliance requirements delay commercial availability of advanced first-mover products.

 

Advanced Wound Care Management Market is Envisaged to Hit US$11,161.6 mn by 2024

The worldwide market for advanced wound care management market is a consolidated one with a few companies that are technologically and scientifically advanced, reports Transparency Market Research (TMR) in a new report. The four top companies, namely Molnlycke Health Care, ConvaTec Group plc., Smith and Nephew, and Acelity L.P. Inc. held close to 65% market share in 2015. These topnotch companies are making significant investments in R&D so as to develop innovative products and stay in the lead. Competitive prices offered by top shots renders intense competition amongst them.

As per the TMR report, the global advanced wound care management market is likely to display a CAGR of 6.3% between 2017 and 2024. Expanding at this rate, the market which stood at US$7,268.1 mn will become worth US$11,161.6 mn by the end of 2024. Among the key product types, advanced wound dressings currently hold leading share in the overall market. Going ahead, the segment is likely to expand at the leading growth rate. Venous leg ulcers, on the basis of type of wound, holds the leading market share due to high incidence of leg ulcer cases.

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Rising Literacy in Developing Countries Accounting for Early Medical Help for Wounds Benefits Market

The advanced wound care management market is primarily driven by the rising incidence of chronic wounds. Chronic wounds generally require longer healing time and if not treated on time can lead to complications. Chronic wounds account for significant burden on public healthcare systems worldwide that have socioeconomic implications. According to statistics, currently more 4.5 million individuals suffer from pressure ulcers and more than 9.7 million individuals with venous ulcers.

Diabetic ulcers – a type of chronic wounds are growing at a rapid pace due to increasing incidence of Type 1 and Type 2 diabetes especially in developed economies. Diabetic ulcers is growing at 9% annually which outpaces the rate of development of new therapeutics. Patient pool of diabetic ulcer patients is currently close to 10.0 million.

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Worldwide, growing elderly population above the age of 65 years is stoking demand for advanced wound care. As per statistics of the U.S. Census Board, individuals above the age of 65 years are estimated to account for 20% of the population by 2030. This population that is susceptible to falls and injuries require longer healing time that can impact quality of life and can also cause social distress. According to the Wound Healing Society, in the U.S., almost 15% individuals above the age of 65 years suffer from chronic wounds, which mainly include venous stasis ulcers, pressure ulcers, and diabetic foot ulcers.

Increasing patient awareness about early treatment of wounds is stoking demand for wound care products. Rising disposable income and increasing literacy especially in developing countries is leading individuals to seek early medical help for wounds before it leads to infection or other complications.

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Apart from this, commercial availability of different skin substitutes for treating chronic wounds is benefitting the advanced wound care management market. Skin substitutes help reduce healing time and reduce the risk of complications associated with burns, trauma, surgical cuts, and skin breakouts.

Limited Reimbursement Scenario Challenges Growth in the U.S.

On the downside, high cost of advanced wound care products over traditional wound dressing account for their limited adoption. For instance, in the U.S., the cost of managing pressure ulcer with advanced wound care products ranges from US$7,000 to US$55,000. Such costs are mostly affordable by the affluent thus makes for a smaller market. Limited reimbursement for advanced wound care products is a restrain to the growth of this market in the U.S.